This lower diagnostic testing price has had the additional benefit of enabling many states to implement CF screening into newborn screening programs. Three or four licenses had lapsed because research on gene therapy failed to progress to market. It is a simple, painless, reliable test that measures the chloride in sweat. Make arrangements to meet with Paula privately at the first opportunity. Thus, CFF research funding can be directly used for research purposes without concern for downstream licensing risks.

Impact of gene patents and licensing practices on access to genetic testing for cystic fibrosis. See other articles in PMC that cite the published article. Mutated CFTR protein results in a buildup of thick, viscous mucus in the lungs, digestive tract, and reproductive system. What is the best response by the nurse? Lap-Chee Tsui and Dr.

Three or four licenses had lapsed because research on gene therapy failed to progress to market.

hesi case study cystic fibrosis

One result of this was a three-year development agreement that Novartis and OneWorld Health signed in to develop anti-diarrheal therapies In spite of the rush to file the patent application, fibrosjs thought and attention were devoted to constructing an appropriate licensing strategy to allow use of the CFTR gene sequence in various applications, including carrier screening, diagnostics, therapeutics, and research. Debbie is able to say her first and last names, and to state her age while holding up 3 fingers.

This meant that the license had to be affordable to small nonprofit operations. Important features of the licensing planning process included thoughtful consideration of potential uses of the patent; anticipation of future scientific discoveries and technological advances; engagement of relevant stakeholders, including the Cystic Fibrosis Foundation; and using separate licenses for in-house diagnostics versus kit manufacture.

Cystic Fibrosis Amidst the Zest for Life in Youth

Which documentation further supports the diagnosis of CF? Interaction with other genes and medical casw of symptoms, like taking measures to prevent infections, add to mutational cae to make the clinical course of CF unpredictable. Part of the fibrksis in CF is due to a large number of genetic mutations that have variable effects on CFTR protein function. However, the main challenge posed by conferring exclusivity to a gene therapy company was that there were several potential venues through which exclusivity could be granted: Some variants do not cause CF symptoms; others are quite severe.


Furthermore, if a patient advocacy organization lacks the monetary resources required to fully fund the initial stages of therapeutic research and to cover the cost of sub-licensing, then this licensing strategy might not be as successful as it has been for the CFTR patents.

Glucose level After surgical clipping of cas ruptured cerebral aneurysm, a client develops the syndrome of inappropriate secretion …. He did this to avoid a conflict of interest in making decisions, and to avoid being dragged into the many controversies over gene patenting and licensing and also, of course, to support the charity —in addition to supporting further CF research.

Discuss the importance of playing games that require Debbie to do physical activity such as running, jumping, or skipping. Impact of gene patents and licensing practices on access to genetic testing for long QT syndrome.

hesi case study cystic fibrosis

What is the best response by the nurse? Had CF diagnostic testing not become as tibrosis as it was, these life expectancy improvements may have been less impressive or happened later. Which clinical manifestation does the nurse expect to increase in a client with Cushing syndrome?

hesi case study cystic fibrosis

The U of M gets a small payment if OneWorld Health sub-licenses to a developer, but gets no running royalties on products or services. The U of M holds all licenses within the U. Indeed, improved management of pulmonary infections is one of the main reasons that mortality and morbidity of CF have dramatically studg.


See other articles in PMC that cite the published article. How about receiving a customized one?

Cystic Fibrosis Patents: A Case Study of Successful Licensing

Which instruction should the Nurse Educator include when discussing respiratory fibrlsis One of the benefits of this arrangement for the U of M is that the CFF handles all the administrative aspects of non-exclusive licenses for CFF research collaborations. The final therapeutic patent is exclusively controlled by Vertex with a royalty agreement to CFFbut if the CFTR Hssi sequence, method, and mutation patents had been exclusively licensed, developing and using ivacaftor would sthdy been contingent on clearing diagnostic rights, making the situation more complex.

A few days after the party, Sarah came down with common cold symptoms that rapidly deteriorated into a serious lung infection. We have a quiet room you can use that is private and close by. What action should the nurse take first?

HESI Case Studies-Pediatrics-Cystic Fibrosis (Debbie Baker) –

At what rate should the nurse set the infusion pump? Managed Care Considerations Posted on: Because the development of any therapeutic would require significant investment from a biotechnology or pharmaceutical company to bring a product through proof of clinical mechanism, clinical testing, and U.

It enabled continuing research, wide-spread CF diagnostic testing and newborn and carrier screening, and facilitated development of CF therapeutics. Not much was known about whether a potential protein-based therapeutic could be developed, since the function of the CFTR heso was not yet known, other than hints it was an ion channel for chloride.